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The New generation of quinolones

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Published by M. Dekker in New York .
Written in English


  • Quinolone antibacterial agents,
  • Anti-Infective Agents, Quinolone -- pharmacology,
  • Bacterial Infections -- drug therapy,
  • Quinolones -- pharmacology

Book details:

Edition Notes

Includes bibliographical references and index.

Statementedited by Clifford Siporin, Carl L. Heifetz, John M. Domagala.
SeriesInfectious disease and therapy ;, v. 5
ContributionsSiporin, Clifford, 1949-, Heifetz, Carl L., 1935-, Domagala, John M., 1951-
LC ClassificationsRM666.Q55 N48 1990
The Physical Object
Paginationxii, 347 p., [2] p. of plates :
Number of Pages347
ID Numbers
Open LibraryOL1852188M
ISBN 100824782240
LC Control Number90003791

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Second and Third Generation Oral Fluoroquinolones. Therapeutic Class • Overview/Summary: The second and third generation quinolones are approved to treat a variety of infections, including dermatologic, gastrointestinal, genitourinary, respiratory, as well as several.   The FDA has set a Prescription Drug User Fee Act (PDUFA) target date of J for the completion of the NDA review. Ozenoxacin is a novel generation of non-fluorinated quinolones . These images are a random sampling from a Bing search on the term "Second Generation Fluoroquinolone." Click on the image (or right click) to open the source website in a new browser window. Search Bing for all related images. New quinolones are continually being developed as bacterial species develop resistance to existing quinolones. This book presents the most current information available in our continual .

Quinolones are a class of potent, broad-spectrum synthetic agents with good bioavailability, oral and intravenous formulations, high serum and tissue levels, and a generally low incidence of side. The first quinolone emerged in the early s, with the isolation of 7-chloro-l-ethyl-1, 4-dihydrooxoquinolinecarboxylic acid, a by-product of the commercial preparation of chloroquine. This compound was found to have anti-bacterial activity and was subsequently modified to produce nalidixic acid, a 1, 8-naphthyridine [ 1 ] (see Fig. 1).   The first quinolone, nalidixic acid (NegGram), was introduced in Since then, structural modifications have resulted in second-, third-, and fourth-generation . Contributor By: Michael Crichton Media PDF ID d9 the new generation of quinolones infectious disease and therapy pdf Favorite eBook Reading a group in which quinolones have not been used routinely the centers for disease control and.